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New research suggests signs of dementia can be detected in blood

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Researchers have reportedly found warning signs that could indicate impending dementia in the blood

In a new study published Monday in the scientific journal “EMBO Molecular Medicine,” scientists from the German Center for Neurodegenerative Diseases (DZNE) and the University Medical Center Göttingen said that certain levels of microRNAs could be harbingers of the condition. 

MicroRNAs are molecules that regulate and influence the production of proteins and are a central process in metabolism.

Combining the analysis of human data and mechanistic studies in model systems, the study’s authors said they identified identify a circulating 3-microRNA signature that reflects key processes associated with the ability of a cell or system of cells to detect perturbation and generate a compensatory response to restore baseline function.

The group analyzed both young and healthy humans with already diagnosed patients in addition to animal and cellular disease models to identify the signature – which also informs about the mechanism by which a pathological condition occurs in the brain and they wrote that targeting the 3-microRNA signature using RNA therapies could enhance disease phenotypes in animal models.

“When symptoms of dementia become noticeable, the brain is already massively damaged. The diagnosis is currently far too late to even have a chance of effective treatment. If dementia is detected early, the chances of positively influencing the course of the disease increase, ” André Fischer, research group leader, spokesperson at the DZNE site in Göttingen and professor at the UMG’s clinic for psychiatry and psychotherapy, said in a press release. “We need tests that ideally respond when dementia has not yet broken out and reliably assess the risk of a later disease. So they warn early on. We are confident that our current study results will pave the way for such tests. “

In healthy individuals, levels of microRNAs correlated with mental fitness and individuals with a lower blood count performed better in cognition testing.

In mice, the researchers found the value rose even before the animals began to exhibit cognitive decline, regardless of the subject’s age or because they had developed symptoms similar to those with Alzheimer’s dementia.

Patients with mild cognitive impairment were found to have an increased blood level of the three microRNAs and 90 percent developed Alzheimer’s disease within two years.

Lastly, the study found that – on mice and cell cultures – the three microRNAs influence inflammatory processes in the brain and “neuroplasticity,” including the ability of nerve cells to connect to one another.

“In our view, they are not only markers but also have an active impact on pathological processes. This makes them potential targets for therapy,” Fischer said. “Indeed, we see in mice that learning ability improves when these microRNAs are blocked with drugs. We’ve observed this in mice with age-related mental deficits, as well as in mice with brain damage similar to that occurring in Alzheimer’s disease.”

While the study suggests that the microRNA signature could be used as a “point-of-care” screening approach to detect individuals at risk for developing Alzheimer’s disease – as well as highlights the potential of RNA therapies to treat it – the technique is not yet suitable for practical use. 

In further studies, Fischer said that the group aims to validate the biomarker clinically.

In the US, of those at least 65 years of age, there were an estimated 5 million adults with dementia in 2014 and there are projected to be nearly 14 million by 2060.

The World Health Organization (WHO) reports that there are currently more than 55 million people with dementia across the globe and nearly 10 million new cases every year.

Age, family history, poor heart health, race and ethnicity and traumatic brain injuries can all increase the risk for dementia, according to the US Centers for Disease Control and Prevention (CDC).

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These fatty foods could be destroying your memory, say scientists

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Ready meals and fast food could be destroying your memory.

Scientists say highly processed foods, crisps, and deli meats containing preservatives were linked with abrupt memory loss in older brains.

Researchers warn the amygdala — the part of the brain which regulates fear — is also affected.

So a bad diet could mean some dangerous decisions.

But diets with extra omega-3 fatty acid DHA, found in fish such as salmon, could ward off problems. Rather than supplements, researchers advised improved diets.

Scientists at America’s Ohio State University Institute for Behavioural Medicine Research did tests on lab rats.

Dr. Ruth Barrientos called the results “alarming”, adding: “Consumption of a processed diet can produce significant and abrupt memory deficits.”

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Biden and Lightfoot know mask rules are idiotic — so why haven’t they changed?

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It happened again because of course it happened again. The latest example of COVID hypocrisy, if you have enough hard-drive space to keep track, is a viral video of President Biden traipsing through a ritzy DC eatery with no mask, in defiance of the city’s strict rules. In Chicago, Mayor Lori Lightfoot was photographed at a basketball game, the only bare face in a sea of muzzled fans.

This kind of thing has been so common that it is hard to stay outraged, even though we should.

But there is another, deeper question at play here. Why won’t the Centers for Disease Control and Prevention update its masking guidance as vaccinations increase, case numbers diminish and politicians, among pretty much everyone else, ignore it across the nation?

The CDC website says that “If you are fully vaccinated, to maximize protection from the Delta variant, and prevent possibly spreading it to others, wear a mask indoors in public, if you are in an area of substantial or high transmission.” A handy map shows the location of these areas — it’s basically the entirety of the United States. This guidance is vague, and not followed by massive swaths of the nation.

Mask mandate hypocrite Chicago Mayor Lori Lightfoot attended a basketball game where everyone except her was wearing a mask.
Mask mandate hypocrite Chicago Mayor Lori Lightfoot attended a basketball game where everyone except her was wearing a mask.
Twitter

Why is it being ignored? Because much of its application is nonsensical on its face, so to speak. What possible health benefit is there for wearing a mask from door to the table then taking it off to eat and drink and talk all night? Every one of us knows that 10 seconds of following the hostess to your table is not a potential superspreader event. It’s such performative idiocy.

Meanwhile, CDC guidelines still say if you take a kid across state lines, say on vacation, you have to quarantine for 10 days. Is any parent in the country actually doing this? We should hope not, because it’s insane. Even Fauci the Merciful, who has relented and has now pronounced we can have holiday gatherings, isn’t mentioning this. Because he knows he would look like a fool.

President Joe Biden leaves Washington DC restaurant Fiola Mare without wearing a face mask.
President Joe Biden leaves Washington DC restaurant Fiola Mare without wearing a face mask.
AP Photo/Manuel Balce Ceneta
President Joe Biden and first lady Jill Biden went to Fiola Mare on October 16, 2021 for a date night.
President Joe Biden and first lady Jill Biden went to Fiola Mare on October 16, 2021 for a date night.
REUTERS/Tom Brenner

So why do these absurd rules, that most people don’t follow anyway, and seem to be based on about as much science as Tarot cards, still exist at all? And more importantly, what metrics do we need to hit for them to go away? That’s one query the exultant and high experts will never answer. When it comes to imposing restrictions the science is strict, settled, and exact, when it comes to easing restrictions it’s all a rich tapestry of who really knows.

Enough. When mask mandates made their first appearance in the Spring of 2020 many feared we would wind up wearing them forever. Those people were mocked as alarmists. Well, it’s almost 2022, what gives? Everyone over 12 can get a vaccine that we are promised gives fantastic protection, and young kids continue to only very rarely have significant illness.

People can decide for themselves whether they want to keep wearing masks, if they are high risk or nervous. As for the rest of us, what are we waiting for? We have long passed common sense. We need some answers about how and when these rules will end. And we need them now.

David Marcus is the author of “Charade: The COVID Lies That Crushed A Nation.”

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Cops face questions after missing Alabama woman’s body found in police van

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A missing Alabama woman’s body has been found in an unoccupied police van — prompting questions about her death and how she could go undetected as authorities were searching for her.

Christina Nance, 29, was discovered dead in a prisoner transport van Oct. 7, five days after she was reported missing, Deputy Police Chief DeWayne McCarver said.

The vehicle was parked at a public safety complex in Huntsville.

“The officer noticed shoes next to the van and approached, discovering Ms. Nance’s body inside. Windows on the van were observed to be opened and on this type of van they popped outward,” McCarver said on Friday at a press conference, CNN reported.

No cause of death has been determined, but preliminary autopsy results didn’t indicate that there was any foul play or bodily trauma.

“The official cause of death will be ruled by the state medical examiner once additional studies, including toxicology, are complete,” police said.

Police released surveillance footage of a woman believed to be Nance wandering through the parking lot on Sept. 25, then appearing to enter the van.

But her family — who reported her missing on Oct. 2 — said they have their doubts about the footage.

“The video was not clear enough to indicate that that was our sister Christina Nance,” Nance’s sister Whitney Nance told news station WAFF.

Police vehicles.
Police released surveillance footage of a woman believed to be Christina Nance wandering through the parking lot on Sept. 25.
Huntsville Police Dept. Facebook

“It was just very heartbreaking to know that we didn’t get the clarification that we really needed, that we wanted.”

Police have said it’s protocol for the vans to be kept locked.

“It is an accountability issue on our part,” McCarver said. “That should not have happened. And now we have to look at that, and we have to make sure that we have things in place so that does not happen again.”

It’s unclear how Nance went undetected in the busy police parking lot.

“Cars go by, people walk nearby the van. We just wish that she would have hollered out to someone or something, because there were plenty of … what we see as potential opportunities for this to not be a tragedy. And unfortunately, no one was able to realize she was in that van and that was the outcome,” McCarver said.

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