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Groundbreaking mRNA vaccine could help cure pancreatic cancer

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A new vaccine using the same mRNA technology as the Pfizer jab against COVID-19 could be a breakthrough in the fight against pancreatic cancer.

In a promising early study conducted by German company BioNTech — which partnered with Pfizer to develop the lifesaving COVID shot — half of the patients remained cancer-free 18 months after having their tumors removed and receiving the jabs.

The groundbreaking trial — led by Dr. Vinod Balachandran at the Memorial Sloan Kettering Cancer Center in Manhattan — presented its promising results at the American Society of Clinical Oncology conference in Chicago on Sunday.

Doctors said the results showed that the vaccine could train the immune system to kill pancreatic cancer cells by boosting immune cells that target tumors.

The trial was carried out on 16 patients, each of which was given eight doses of the individualized vaccine made using the mRNA genetic code found in each of their tumors.

Ugur Sahin, Özlem Türeci
BioNTech co-founder and chief medical officer, Prof Özlem Türeci (right), has called the results of the trial “promising.”
ZUMAPRESS.com

The patients received their jabs after undergoing surgery to remove a tumor.

Results showed the jab produced a T Cell response in eight out of the 16 patients, who remained cancer-free throughout the duration of the trial.

The remaining patients who did not respond to the vaccine either died or saw their cancer return.

“Unlike some of the other immunotherapies, these mRNA vaccines do appear to have the ability to stimulate immune responses in pancreatic cancer patients,” Dr. Balachandran said of the promising preliminary results.

“So we’re very excited about that, and the early results that suggest that if you have an immune response you may have a better outcome.”

Pancreatic cancer is among the leading causes of cancer-related deaths in the US with 90 percent of patients dying within two years of their diagnosis, BioNTech noted.

The German biotech company heralded the early trial as “encouraging.”

“We are committed to take up this challenge by leveraging our long-standing research in cancer vaccinology and are trying to break new ground in the treatment of such hard-to-treat tumors,” BioNTech co-founder and chief medical officer, Prof Özlem Türeci, said.

“The results of this Phase 1 study are encouraging. We look forward to further evaluating these early results in a larger randomized study,” he added.

Dr. Balachandran added the results should be welcome news for other cancer patients too.

“Pancreatic cancer has been the poster child for a cancer that is very difficult to treat with traditional chemotherapies and immunotherapies,” he said.

“Any ability to treat pancreatic cancer with a new therapy hopefully paves the way for us to now test [mRNA cancer vaccines] more broadly.”

Woman in heavy protective gear grabbing bottle.
Doctors said the results showed that the vaccine could train the immune system to kill pancreatic cancer cells by boosting immune cells that target tumors.
Associated Press

The hopeful results come as another exciting study conducted on 18 rectal cancer patients had a 100 percent success rate, according to a paper published Sunday in the New England Journal of Medicine.

In addition to not needing further treatment to eradicate the disease, there were no instances of a recurrence of cancer in the patients during follow-up appointments from six to 25 months after the trial ended.

But while encouraging, doctors noted that the study is small and the results would need to be replicated.

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What Time Will ‘Riverdale’ Season 6 Be on Netflix?

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The season finale of Riverdale aired in late July on The CW. Notice we said season finale? Thankfully, the beloved series will return for a seventh season, but, unfortunately, Season 7 will be the final installment of Riverdale.

If you already streamed the current season, make sure to read Alex Zalben’s interview with Riverdale showrunner Roberto Aguirre-Sacasa on Decider. If you’re waiting to binge Season 6 on Netflix, well, you better clear your calendar because all 22 episodes are about to drop on the streamer. What time will the sixth season of Riverdale debut on Netflix? What time does Netflix release shows? Here’s everything you need to know.

WHEN IS THE RIVERDALE SEASON 6 NETFLIX RELEASE DATE?

Riverdale Season 6 premieres Sunday, August 7 on Netflix.

HOW MANY EPISODES ARE IN RIVERDALE SEASON 6?

The sixth season of Riverdale consists of 22 episodes.

WHAT TIME DOES NETFLIX RELEASE NEW SHOWS?

Netflix releases new episodes at 3:00 a.m. ET/12:00 a.m. PT.

WHAT TIME WILL RIVERDALE SEASON 6 BE ON NETFLIX?

Netflix is based out of California, so Riverdale Season 6 will be available to stream at 12:00 a.m. Pacific Standard Time (3:00 a.m. Eastern Standard Time) beginning Sunday, August 7. If the clock strikes 12:00 (or 3:00 a.m. for folks on the East Coast) and you don’t see the new episodes, give it a moment, hit refresh, and then enjoy the show!

WILL THERE BE A SEASON 7 OF RIVERDALE?

Yes! Decider recently covered that very topic.

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Actress Anne Heche Suffers Severe Burns After Crashing Car Into Los Angeles Home

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Actress Anne Heche, known for her roles in such films as Donnie Brasco, Volcano and I Know What You Did Last Summer, was involved in a fiery car crash in the Mar Vista area of Los Angeles on Friday.

According to TMZ, Heche was driving a blue Mini Cooper and had first crashed into the garage of an apartment complex. Residents of the apartment complex tried to get her out of the vehicle but she backed up and sped off.

Footage of Heche speeding down the streets of her neighborhood had been obtained by TMZ as well as her initial encounter at the apartment complex.

In the first clip, you can hear her car crash towards the end. It has been reported that the actress crashed into someone’s home, causing her vehicle and the house to erupt into flames. Heche suffered severe burns and was resisting being taken away in a stretcher. You can also view footage of this via the TMZ article.

It has not been confirmed whether alcohol has been involved in the incident since her condition prevents doctors from performing any tests to determine if she was driving under the influence. She is currently intubated in the hospital but expected to live.

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These are the vulgar license-plate requests the DMV has rejected

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Stay CL4SSY, New York!

The state Department of Motor Vehicles nixed 3,752 requests for vanity license plates in the last three years because it deemed them too raunchy, radical or simply ridiculous.

New York’s personalized plates go for $60 initially, and then $31.25 annually for renewal. You can get any plate as long as no one else has it and it’s not offensive.

Odds are a request for a plate that marks a wedding anniversary or shows your allegiance to a team — like METS86 — will pass muster with the DMV gatekeepers.

Vulgarity won’t get you to first base.

So plates with the phrase LFGM — the acronym for Pete Alonso’s “Let’s F–king Go Mets” rallying cry — did not make the cut.

And you won’t see anyone driving around with the custom plates MILFDAD, AS5M4N and WLHUNG.

Crude meanings such as “MILFDAD” are unacceptable by the DMV.
Crude meanings such as “MILFDAD” are unacceptable by the DMV.
New York DMV
NYC123
New York state Department of Motor Vehicles denied more than 3.5 thousand requests for license plates deemed inappropriate.
New York DMV
“AS5M4N” was rejected for referring to “Ass man.”
“AS5M4N” was rejected for referring to “Ass man.”
New York DMV

The DMV also put NICEBUNS, FATFANNY, GOTAPOOP and BENDOVER in the rear-view mirror.

One player unsuccessfully tried to score the plate YESDADDY, to no avail.

The DMV also shot down such dark requests as DEADGIRL, GENOC1DE, S8TAN, DETONATE and MURDERM3.

“SUM8ITCH” is not allowed.
“SUM8ITCH” is not allowed.
New York DMV
The DMV thoroughly nixed a request for “CNNLIES.”
The DMV thoroughly nixed a request for “CNNLIES.”
New York DMV
BOOBIE is prohibited.
BOOBIE is prohibited.
New York DMV

Getting political is a dead end too — FJOEBIDN, FDTRUMP and CNNLIES were nixed.

LUDEDUDE, NARCO, GOT METH and BLUNT also went up in smoke.

Staten Island attorney Bill Dertinger said his blue 1995 Jaguar SJS was tagged with ESQLTD after his company and his 2014 Porsche had the plate GHOSTGTS because the sleek sportscar was white.

“The plates can make you stand out — which can be a curse or a blessing,” the 54-year-old Dertinger said. “Make sure you don’t cut anybody off.”

A man attempted to sneak in “YESDADDY” onto his license plate.
A man attempted to sneak in “YESDADDY” onto his license plate.
New York DMV
The DMV stopped a request for “FJOEBIDEN.”
The DMV stopped a request for “FJOEBIDEN.”
New York DMV
The DMV also rejects any license plates referring to politics.
The DMV also rejects any license plates referring to politics.
New York DMV

There must be a New York Jets fan playing referee at the DMV because a request for the seemingly innocent plate GASE was sidelined. Ex-Jets head coach Adam Gase had an offensive 9-23 win-loss record during his forgettable two-year tenure.

The DMV would not reveal who gives the final yea or nay.

“The DMV reviews all custom license plate requests and works hard to ensure that any combinations that may be considered objectionable are rejected,” said agency spokesman Tim O’Brien.

“GLOCKS” referring to guns is not accepted by the DMV.
“GLOCKS” referring to guns is not accepted by the DMV.
New York DMV
“FLYMOFO” is not approved by the DMV.
“FLYMOFO” is not approved by the DMV.
New York DMV

He said guidelines on what plate combinations are restricted can be found on the DMV website: https://dmv.ny.gov/learn-about-personalized-plates. Approximately 50,000 personalized and custom plates are sold per year, O’Brien said.

Bagged Tags

The state DMV has rejected 3,752 requests for custom license plates in the last three years because it deemed them potentially offensive. Here are some:

YESDADDY

FJOEBIDN

FDTRUMP

GLOCKS

FLYMOFO

BOOBIE

AS5M4N

BUDLIGHT

DEADGIRL

SUM8ITCH

GENOC1DE

S8TAN

CNNLIES

DETONATE

MURDERM3

MILFDAD

WLHUNG

Source: NYS DMV

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